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KMID : 1030220170180010014
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Journal of Korean Diabetes
2017 Volume.18 No. 1 p.14 ~ p.19
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The Effects of Diabetes on Risk of Infection
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Seo Ji-A
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Abstract
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A relationship between diabetes and infection has long been accepted clinically. Host-specific factors that are thought to predispose diabetic patients to infection include hyperglycemia-related impairment of the immune response, vascular insufficiency, diabetic peripheral and autonomic neuropathy, and skin and mucosal colonization of pathogens. Some uncommon but life-threatening infections (e.g., malignant otitis media, rhinocerebral mucormycosis, gangrenous cholecystitis) occur almost exclusively in people with diabetes. Previous large population-based observational studies have reported strong associations between higher HbA1c and infection risks for both type 1 and type 2 diabetes. However, the potential of better long-term glycemic control to prevent infection remains controversial due to sparse randomized
controlled trials. More high-quality, prospective studies with sufficient control of confounding factors and repeated HbA1c measures are necessary.
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KEYWORD
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Diabetes mellitus, Hyperglycemia, Infection
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